Caffeine can also protect against the debilitating effects of dementia,a new study has revealed. Scientists say that drug increases the power of an enzyme in the brain that protects neurons and fight misfoldedproteins. Today, 47.5 million people living with dementia, and that number is set to increase to 115.4 million by 2050 by the aging of the population. The researchers hope that caffeine, which is consumed bythe majority of the adult population, can help slow the progression of the disease of degeneration. Previously, the researchers found thatthe enzyme, called NMNAT2, serves two functions in the brain. The first is a function of protection to protect neurons from the stress andthe second is a 'chaperone function' misfolded protein called tau, that accumulate in the brain as 'plates' due to aging combat. Buildup ofplaque in the brain is a well-known precursor of serious neurodegenerative diseases. Misfolded proteins also have been associated with disorders such as Alzheimer's, Parkinson's, Huntington disease diseases such as sclerosis from amyotrophic-lateral - better known as ALS orLou Gehrig's disease. The most common form of these disorders, Alzheimer's disease affects more than 5.4 million Americans, with the numbers expected to increase the age of the population. The study, conducted by Indiana University Bloomington, had projected about 1,280 compounds, including existing drugs and had been tested inmice. The team identified 24 compounds - and caffeine in particular -to have an increase in the production of NMNAT2 in the brain. Caffeine had been demonstrated previously that improve the memory function in mice with high levels of misfolded protein tau. Researchers modified mice given caffeine to produce low levels of NMNAT2. Thesemice began to produce the same levels of the enzyme than normalmice.
Another compound which is to strongly encourage the production ofNMNAT2 in the brain was the rolipram, an 'orphan drug' - a pharmaceutical that remains undeveloped commercially.
Rolipram, as an antidepressant, was discontinued in the mid-1990s.However, researchers interested by compound by several other studies also follow sample evidence which could reduce the impact of entangled in the brain proteins.
'It is so important to identify compounds that could play a role in thefuture treatment of these debilitating of mental disorders, increase our knowledge about the pathways in the brain that seem to naturallycause the decrease of this protein is required, said lead author Professor Hui Chen Lu, Professor of psychological and brain in Indiana University Sciences.
'This paper could help advance efforts to develop drugs that increaselevels of this enzyme in the brain, creating a chemical 'blocking' against the debilitating effects of neurodegenerative diseases'. Caffeine has been shown in several studies have a number of other benefits in the brain. Not only it is a stimulant, but also blocks the receptors for achemical called adenosine.
Adenosine prevents the release of brain chemicals, which, when it flows freely, gives you increased energy and potentially improve mentalperformance and slow age-related mental decline.
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It reduces the risk of depression
A study of 10 years of 86,000 nurses women showed a reduction in the risk of suicide in coffee drinkers. Another study, conducted by theschool of public health at Harvard, found that women who drank four or more cups of coffee were 20 percent less likely to suffer from depression.
Increasing fiber intake
A cup of coffee represents a contribution of up to 1.8 grams of fiber intake recommended between 20 to 38 grams.
Reduces risk of multiple sclerosis
A study by 2015 showed that at least four cups of coffee a day may help protect against the development and recurrence of Ms.
It is believed that coffee prevents neuronal inflammation possibly leading to the development of the disease.
Help to burn fat the caffeine is one of the few natural substances that have been proven to help burn fat.
Several studies have shown that caffeine to increase the rate metabolic between three and 11 percent.
Other studies have shown that caffeine can increase specifically the burning of fat, for as much as 10 percent in obese individuals and 29 percent for people to read.
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