Drugs guided by magnets to zero in on blood clots are set to revolutionise the treatment of stroke and heart patients.
Biochemists have combined thrombolytics with magnetic particles tocreate 'nanospheres' of medications that can be aimed at specific points of the body. Medicine is guided by an external electromagnetic field and sent exactly where it is needed instead of flooding the entirebody. Delivery of medicines in this way could make 1,000 times moreeffective, tests on animals have demonstrated. Higher concentrationsof medicine may also be used as there is little risk of damaging tissuein healthy parts of the body. In patients who suffer a stroke after theform of a blood clot in his brain, drugs are used to clear the blockageand restore the blood supply. The treatment is often the difference between life and death. But the current drugs are powerful and very toxic and in many cases may not be or cause serious side effects. Be able to handle drugs precisely where needed could make them work better, reduce side effects and increase the number of patients that could lead them. Scientists in ITMO University in St. Petersburg, Russia, who developed the technique of said the magnetic nanospheres can be simply injected into the bloodstream and then directed to the clotwith magnets. In stroke patients, quickly get rid of blockages in the blood vessels in the brain dramatically can improve the chances of recovery. The researchers, whose study is published in the journal reports scientific, used an enzyme natural known as urokinase combined with magnetite, a molecule of iron. This created magnetic nanospheresapproximately 10,000 times smaller than the width of a human hair. If they are successful initial tests on rabbits, the first trials in humans could be held within two years. Researchers said the technology couldbe adapted to carry chemotherapy for cancer patients to help reducethe damage to healthy cells.
Tuesday, March 14, 2017
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